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Integration of information from all mRNA-seq read classes including SJs led to genome reannotations specifically relevant for the species used rat , the anatomical site studied DRG , and the neurological disease considered pain ; for example, a exon coreceptor for the nociceptive transmitter substance P was identified, and
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The Food and Drug Administration FDA is holding a public workshop to discuss factors FDA should consider when evaluating drugs for orphan designation that treat a tissue agnostic disease or condition in oncology, and additional factors related to orphan exclusivity FDA should consider when approving a product with a tissue agnostic indication. Because the continued development of targeted therapies based on molecular markers has the potential to alter the landscape of orphan drug development, FDA is holding the public workshop to obtain input on the complex scientific and regulatory issues surrounding tissue agnostic therapies in oncology and the appropriate application of orphan drug incentives in that paradigm.
The entrance for public hearing participants non-FDA employees is through Building 1 where routine security check procedures will be performed. If you wish to attend the public workshop in person, please register by Wednesday, April 25, at 5 p. Eastern Time. FDA will provide a free-of-charge live webcast for viewing the public workshop.